Side effect of statins trial#

This is because the overall benefit in terms of health and wellbeing of taking statins and preventing a heart attack or stroke is seen to be greater than the consequences of developing diabetes. However, it is usually recommended that people at risk of diabetes do take statins if they are needed to help lower their cholesterol. There is a small chance that statins may increase your risk of getting type 2 diabetes. Rhabdomyolisis can be caused by an interaction between statins and some other medicines including antibiotics. Your doctor will also want to check for a rare but serious condition called rhabdomyolisis and will check any other medicines you are taking. you may discuss stopping taking your statin with your doctor.The evidence showing that statins may cause irritability and. Yet all medications can cause side effects, and statins are no exception. you may choose to continue living with the aches because of the benefits of the statin, or These groups agree that most people tolerate statins well.a lower dose or a different statin may be prescribed, or.Your doctor will check an enzyme called creatine kinase to see if the aches and pains are possibly being caused or made worse by the statins. If your pain is severe, sudden or comes on shortly after you start your statin see your doctor. This is rarely serious and often goes away with time. Some people will have muscle pain or weakness when taking statins. There are also reports that statins may affect cognitive function, mainly memory loss and confusion, and affect sleep and mood but these have not been fully proven. These risks are thought to balance each other out. an increased risk of stroke caused by a bleed in the brain however, there is also a lower risk of stroke caused by a blocked blood vessel.an increased risk of developing type 2 diabetes ( see below).muscle pain or weakness (called myopathy, see below).The most common side effects are tummy upset such as indigestion, bloating, flatulence (wind), headache, and stuffy nose. More than 200 million people around the world take statin drugs for their heart health, according to John Hopkins Medicine.Most people have few, if any, side effects from statins.

Side effect of statins trial#

'This normally would not be practical in a clinical trial or for such a large sample size, but genetic analyses such as the one we have conducted can really help with drug safety profiling by uncovering links with diseases and biomarkers,' Prof Hypponen says. The latter are a newer class of drug so less is known about their long-term safety.Ĭhief investigator Professor Elina Hypponen, Centre Director of the Australian Centre for Precision Health at UniSA, says genetic information was used to compare the outcomes of a range of LDL-C lowering drugs, working in different ways. 'These findings help us to understand how people may react to different drugs and assess the viability of new drug pathways.'Ĭompared to statins, which inhibit the production of cholesterol, PCSK9 drugs destroy cholesterol in the cells. 'Our study reveals associations with lung function and brain size, which may influence how these drugs are prescribed or repurposed in the future,' Pham says. UniSA PhD student Kitty Pham, lead author of the paper, says the findings highlight the importance of delving deeper to understand potential long-term effects of different medications. One unexpected benefit of taking statins was found, with some people seeing an increase in brain volume of the hippocampus, which may reduce the risk of dementia and depression. Statins are the most common cholesterol lowering medication prescribed. Genetic variants reflecting another cholesterol lowering medication, statins, were found to correlate with higher BMI and body fat, as well as reduced testosterone. However, lipid lowering medications that clear cholesterol from the cells - known as PCSK9 inhibitors - could impair lung function and further studies are needed on their long-term side effects, researchers say. It does not cause any other adverse health conditions except diarrhea in some people. In the vast number of cases, medication prescribed for high cholesterol does what it promises: significantly lowers the risk of cardiovascular disease, high blood pressure, diabetes, and age-related diseases. The outcomes have been published in the British Journal of Clinical Pharmacology. Genetic data from 340,000 UK Biobank participants was analysed to explore the risks and benefits of LDL-C drugs. That's the finding from a recent University of South Australia study, the first in the world to compare cholesterol lowering medications (LDL-C drugs) to a range of clinical and heart and brain MRI biomarkers.